Diagnosis of indolent systemic mastocytosis in a patient with “seborrheic keratosis”
نویسندگان
چکیده
منابع مشابه
Delayed Diagnosis of Adult Indolent Systemic Mastocytosis
Systemic mastocytosis (SM) is a rare, heterogeneous disorder characterized by infiltration and accumulation of mast cells within multiple organs, most commonly the skin. Given the rarity of the disease and the fact that many of its symptoms are shared by more common disorders, a diagnosis may be delayed or hindered. These patients have an elevated risk of developing potentially life-threatening...
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Systemic mastocytosis is a clonal disorder of the mast cell and its progenitor cell. It is a rare disorder with unknown incidence in Greece, with an estimate of 2 cases per year in Great Britain. We present a case of an asymptomatic, 72-year-old man who was found to have ileocolitis on endoscopy. Histology revealed mast cells in lamina propria >15 HPF and biochemistry showed high levels of seru...
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circular macules, less than 1 cm in diameter, located on his trunk and extremities [Figure A]. Wheals and surrounding erythema developed in the lesions after rubbing (positive Darier sign). Laboratory analyses showed mild eosinophilia with an increased total tryptase level of 40 ng/ml. Densitometry was normal. With the strong clinical suspicion of cutaneous mastocytosis, a skin biopsy was perfo...
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Hailey-Hailey disease (HHD) or familial benign chronic pemphigus is a dermatosis with an autosomal dominant inheritance characterized by full penetrance and variable expressivity: from individual resembling eczema lesions to extensive lesions of the skin. HHD causes mutations in the gene ATP2C1, which encodes the ATPase calcium-magnesium secretory mechanism of a human [1,2]. The mechanism by wh...
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A 58 year old man was referred to suegery clinic due to dyspnea and left sided chest wall pain for three months duration.during the last 18 months some monomorph disseminated hyperkeratotic skin lesions appeared on his face and trunk.after worlup and evaluation of the patient,he underwent thoracotomy with indication of presence of a mass in the left lung.the operative finding was a huge solid r...
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ژورنال
عنوان ژورنال: Hematology, Transfusion and Cell Therapy
سال: 2021
ISSN: 2531-1379
DOI: 10.1016/j.htct.2020.10.968